Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described. A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagon...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-12, Vol.11 (24), p.3099-3102
Hauptverfasser:	Kim, Dooseop, Wang, Liping, Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Carver, Gwen, Carella, Anthony, Holmes, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CCR5 Receptor Antagonists HIV Infections - drug therapy HIV-1 - isolation & purification Humans Hydantoins - chemistry Hydantoins - pharmacology Hydantoins - therapeutic use Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described. A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00654-0