Ribonuclease P: a ribonucleoprotein enzyme
The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5′ end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA–P-protein and RNase-P-RNA–precursor-tRNA complexes, as well as on the positions of cata...
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| Veröffentlicht in: | Current Opinion in Chemical Biology 2000-10, Vol.4 (5), p.553-558 |
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| container_title | Current Opinion in Chemical Biology |
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| creator | Kurz, Jeffrey C Fierke, Carol A |
| description | The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5′ end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA–P-protein and RNase-P-RNA–precursor-tRNA complexes, as well as on the positions of catalytic metal ions, emphasizing the importance of the structure to the catalytic function. |
| doi_str_mv | 10.1016/S1367-5931(00)00131-9 |
| format | Article |
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| ispartof | Current Opinion in Chemical Biology, 2000-10, Vol.4 (5), p.553-558 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Base Sequence Catalysis Endoribonucleases - chemistry Endoribonucleases - metabolism NAIM Nucleic Acid Conformation Ribonuclease P RNA, Catalytic - chemistry RNA, Catalytic - metabolism RNA, Transfer, Asp - chemistry RNA, Transfer, Asp - metabolism Substrate recognition Substrate Specificity tRNA |
| title | Ribonuclease P: a ribonucleoprotein enzyme |
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