Ribonuclease P: a ribonucleoprotein enzyme

The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5′ end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA–P-protein and RNase-P-RNA–precursor-tRNA complexes, as well as on the positions of cata...

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Veröffentlicht in:	Current Opinion in Chemical Biology 2000-10, Vol.4 (5), p.553-558
Hauptverfasser:	Kurz, Jeffrey C, Fierke, Carol A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Catalysis Endoribonucleases - chemistry Endoribonucleases - metabolism NAIM Nucleic Acid Conformation Ribonuclease P RNA, Catalytic - chemistry RNA, Catalytic - metabolism RNA, Transfer, Asp - chemistry RNA, Transfer, Asp - metabolism Substrate recognition Substrate Specificity tRNA
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Beschreibung
Zusammenfassung:	The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5′ end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA–P-protein and RNase-P-RNA–precursor-tRNA complexes, as well as on the positions of catalytic metal ions, emphasizing the importance of the structure to the catalytic function.
ISSN:	1367-5931 1879-0402
DOI:	10.1016/S1367-5931(00)00131-9