Dantrolene ameliorates delayed cell death and concomitant DNA fragmentation in the rat hippocampal CA1 neurons subjected to mild ischemia
The present study investigated whether dantrolene, which inhibits the Ca 2+ release from the intracellular Ca 2+ store sites, reduced nuclear DNA fragmentation and produced neuronal protection in a model of global forebrain ischemia. Male Wistar rats were subjected to four-vessel occlusion (4VO) for...
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Veröffentlicht in: | Resuscitation 2001-07, Vol.50 (1), p.117-125 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The present study investigated whether dantrolene, which inhibits the Ca
2+ release from the intracellular Ca
2+ store sites, reduced nuclear DNA fragmentation and produced neuronal protection in a model of global forebrain ischemia. Male Wistar rats were subjected to four-vessel occlusion (4VO) for 5 min and then infused continuously with dantrolene or vehicle into the cerebral ventricle for 3 days. The intact rats did not undergo any intervention. The number of viable and DNA nick-end-labeled neurons in the hippocampal CA1 were evaluated 4 days after the ischemia. The number of viable neurons in the dantrolene-treated rats was significantly higher than that in the vehicle-treated rats and lower than that in the intact animals (
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ISSN: | 0300-9572 1873-1570 |
DOI: | 10.1016/S0300-9572(00)00369-5 |