Cacofurans A and B, New Furanoditerpenes from a Marine Sponge

Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-11, Vol.64 (11), p.1468-1470
Hauptverfasser:	Tanaka, Junichi, Marriott, Gerard, Higa, Tatsunori, Higa, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cacofuran A cacofuran B Cacospongia Chromatography, High Pressure Liquid Convolvulaceae - chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Dose-Response Relationship, Drug Furanoditerpenes Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology Japan Leukemia, Lymphoid Male Medical sciences Mice Molecular Conformation Molecular Structure natural products Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Rats Sea Urchins - drug effects Sea Urchins - embryology Spermatozoa - drug effects Stereoisomerism Tumor Cells, Cultured - drug effects Urinary Bladder Neoplasms X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchin eggs at concentrations of 0.5 and 5 μg/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010203g