Choriocarcinoma-like human chorionic gonadotrophin (HCG) and HCG bioactivity during the first trimester of pregnancy

The objective of this study was to evaluate the distribution of choriocarcinoma-like human chorionic gonadotrophin (HCG) isoforms during first trimester pregnancy and their relationship with in-vitro HCG bioactivity. This was done by means of a retrospective analysis of patients' sera with firs...

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Veröffentlicht in:	Human reproduction (Oxford) 2000-10, Vol.15 (10), p.2209-2214
Hauptverfasser:	Mock, Pascal, Kovalevskaya, Galina, O'Connor, John F., Campana, Aldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amenorrhea - blood Animals bioactivity Biological and medical sciences Biological Assay - methods choriocarcinoma Chorionic Gonadotropin - blood Chorionic Gonadotropin - immunology Chorionic Gonadotropin - metabolism Female Fundamental and applied biological sciences. Psychology HCG Humans Leydig Cells - immunology Leydig Cells - metabolism Male Mice monoclonal antibodies Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy Pregnancy Trimester, First - blood Pregnancy, Ectopic - blood Pregnancy. Parturition. Lactation Protein Isoforms - blood Protein Isoforms - metabolism Retrospective Studies Vertebrates: reproduction
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Zusammenfassung:	The objective of this study was to evaluate the distribution of choriocarcinoma-like human chorionic gonadotrophin (HCG) isoforms during first trimester pregnancy and their relationship with in-vitro HCG bioactivity. This was done by means of a retrospective analysis of patients' sera with first trimester normal intrauterine and abnormal (ectopic) pregnancies. Serum samples were obtained from 38 women with an amenorrhoea of
ISSN:	0268-1161 1460-2350 1460-2350
DOI:	10.1093/humrep/15.10.2209