Hydrogen bonding in salicylsalicylic acid (salsalate) crystals

An X-ray crystallographic study of the drug salicylsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. In addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bondi...

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Veröffentlicht in:	International journal of pharmaceutics 2000-08, Vol.204 (1), p.133-136
Hauptverfasser:	Cox, Philip J., Gilmour, Graham I., MacManus, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Crystallization Crystallography, X-Ray Crystals General pharmacology Hydrogen Bonding Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Salicylates - chemistry Salsalate X-ray crystallography
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Beschreibung
Zusammenfassung:	An X-ray crystallographic study of the drug salicylsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. In addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bonding motifs within a single crystal.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/S0378-5173(00)00495-6