Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes

Cuparene-type sesquiterpenes were isolated from a culture broth of Flammulina velutipes (Curt.:Fr.) Sing. Using spectroscopic methods (HR-MS, 1H and 13C NMR, and 2D NMR, spectroscopy), their structures were determined to be 2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1-benzoxe...

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Veröffentlicht in:	Phytochemistry (Oxford) 2000-08, Vol.54 (8), p.777-782
Hauptverfasser:	Ishikawa, Noemia Kazue, Yamaji, Keiko, Tahara, Satoshi, Fukushi, Yukiharu, Takahashi, Kunihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antimicrobial activity Basidiomycota Basidiomycota - chemistry Basidiomycota - cytology Benzoquinones - chemistry Benzoquinones - isolation & purification Benzoquinones - pharmacology Benzoxepins - chemistry Benzoxepins - isolation & purification Benzoxepins - pharmacology Biological and medical sciences Chemical constitution Cuparene-type Enokipodin A Enokipodin B Enokitake Flammulina velutipes Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Microbial Sensitivity Tests Oxidation-Reduction Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Sesquiterpenoid Spectrum Analysis Tricolomataceae
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Zusammenfassung:	Cuparene-type sesquiterpenes were isolated from a culture broth of Flammulina velutipes (Curt.:Fr.) Sing. Using spectroscopic methods (HR-MS, 1H and 13C NMR, and 2D NMR, spectroscopy), their structures were determined to be 2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1-benzoxepin and 5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone. Both showed antimicrobial activity against Cladosporium herbarum and Bacillus subtilis.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(00)00189-8