Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats

1 Département de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5014, Faculté de Pharmacie, Lyon, 69373 France; and 2 Department of Pharmacology, Second Military Medical University, Shanghai, 200433 Peoples Republic of China This study examined the effect of norepinephrine reuptake blockade with desipramine (DMI) on the spontaneous variability of the simultaneously recorded arterial pressure (AP) and renal sympathetic nerve activity (SNA) in conscious rats. Acute DMI administration (2 mg/kg iv) depressed AP Mayer waves (~0.4 Hz) and increased low-frequency (