Comparative analysis of age-related changes in activities of monoamine oxidase-B and antioxidant defense enzymes in various structures of human brain

Comparative analysis of age-related changes in activities of monoamine oxidase-B and antioxidant defense enzymes in various structures of human brain

Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2001-08, Vol.132 (2), p.760-762
Hauptverfasser: Volchegorskii, I A, Shemyakov, S E, Turygin, V V, Malinovskaya, N V
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Aging - metabolism
Antioxidants - metabolism
Basal Ganglia - enzymology
Brain - enzymology
Brain Stem - enzymology
Catalase - metabolism
Cerebellum - enzymology
Ceruloplasmin - metabolism
Female
Humans
Male
Middle Aged
Monoamine Oxidase - metabolism
Neocortex - enzymology
Superoxide Dismutase - metabolism
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Zusammenfassung:Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia, and stem structures increased with age, while SOD activity decreased and catalase and ceruloplasmin concentrations slightly increased. A contribution of age-related increase of cerebral monoamine oxidase activity into ontogenetic impairment of the antioxidant defense in human brain is discussed.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1013081912452