Interleukin-8 receptor antagonists in pulmonary diseases
Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines are involved in the function of...
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| Veröffentlicht in: | Current Opinion in Pharmacology 2001-06, Vol.1 (3), p.242-247 |
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| container_title | Current Opinion in Pharmacology |
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| creator | Hay, Douglas W.P Sarau, Henry M |
| description | Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in several lung diseases. Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of interleukin-8 and related chemokines in the pathophysiology of lung diseases. |
| doi_str_mv | 10.1016/S1471-4892(01)00043-1 |
| format | Article |
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Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in several lung diseases. Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of interleukin-8 and related chemokines in the pathophysiology of lung diseases.</description><identifier>ISSN: 1471-4892</identifier><identifier>EISSN: 1471-4973</identifier><identifier>DOI: 10.1016/S1471-4892(01)00043-1</identifier><identifier>PMID: 11712746</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; chemokines ; Humans ; interleukin-8 ; Interleukin-8 - metabolism ; Interleukin-8 - physiology ; lung disease ; Lung Diseases - drug therapy ; neutrophils ; Receptors, Interleukin-8A - antagonists & inhibitors ; Receptors, Interleukin-8A - physiology ; therapy</subject><ispartof>Current Opinion in Pharmacology, 2001-06, Vol.1 (3), p.242-247</ispartof><rights>2001 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-fc72dbe00fcc7a45fb8d64c43cebc1db1a18819f294fed1ace02d7c3ea6300aa3</citedby><cites>FETCH-LOGICAL-c276t-fc72dbe00fcc7a45fb8d64c43cebc1db1a18819f294fed1ace02d7c3ea6300aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1471489201000431$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11712746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hay, Douglas W.P</creatorcontrib><creatorcontrib>Sarau, Henry M</creatorcontrib><title>Interleukin-8 receptor antagonists in pulmonary diseases</title><title>Current Opinion in Pharmacology</title><addtitle>Curr Opin Pharmacol</addtitle><description>Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in several lung diseases. Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of interleukin-8 and related chemokines in the pathophysiology of lung diseases.</description><subject>Animals</subject><subject>chemokines</subject><subject>Humans</subject><subject>interleukin-8</subject><subject>Interleukin-8 - metabolism</subject><subject>Interleukin-8 - physiology</subject><subject>lung disease</subject><subject>Lung Diseases - drug therapy</subject><subject>neutrophils</subject><subject>Receptors, Interleukin-8A - antagonists & inhibitors</subject><subject>Receptors, Interleukin-8A - physiology</subject><subject>therapy</subject><issn>1471-4892</issn><issn>1471-4973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7rr6E5SeRA_VTJM27Ulk8bGw4EE9hzSZSrRNa9IK_nu72xWPnmYYvnl9hJwCvQIK2fUzcAExz4vkgsIlpZSzGPbIfCoXgu3_5iMyI0chvFMKKWPikMwABCSCZ3OSr1yPvsbhw7o4jzxq7PrWR8r16q11NvQhsi7qhrppnfLfkbEBVcBwTA4qVQc82cUFeb2_e1k-xuunh9Xydh3rRGR9XGmRmBIprbQWiqdVmZuMa840lhpMCQryHIoqKXiFBpRGmhihGaqMUaoUW5DzaW7n288BQy8bGzTWtXLYDkGKJMk54-kIphOofRuCx0p23jbjyRKo3CiTW2Vy40NSkFtlEsa-s92CoWzQ_HXtHI3AzQTg-OaXRS-Dtug0Gjvq6qVp7T8rfgBjX3xn</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Hay, Douglas W.P</creator><creator>Sarau, Henry M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Interleukin-8 receptor antagonists in pulmonary diseases</title><author>Hay, Douglas W.P ; Sarau, Henry M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-fc72dbe00fcc7a45fb8d64c43cebc1db1a18819f294fed1ace02d7c3ea6300aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>chemokines</topic><topic>Humans</topic><topic>interleukin-8</topic><topic>Interleukin-8 - metabolism</topic><topic>Interleukin-8 - physiology</topic><topic>lung disease</topic><topic>Lung Diseases - drug therapy</topic><topic>neutrophils</topic><topic>Receptors, Interleukin-8A - antagonists & inhibitors</topic><topic>Receptors, Interleukin-8A - physiology</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hay, Douglas W.P</creatorcontrib><creatorcontrib>Sarau, Henry M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hay, Douglas W.P</au><au>Sarau, Henry M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-8 receptor antagonists in pulmonary diseases</atitle><jtitle>Current Opinion in Pharmacology</jtitle><addtitle>Curr Opin Pharmacol</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>1</volume><issue>3</issue><spage>242</spage><epage>247</epage><pages>242-247</pages><issn>1471-4892</issn><eissn>1471-4973</eissn><abstract>Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. 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| ispartof | Current Opinion in Pharmacology, 2001-06, Vol.1 (3), p.242-247 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals chemokines Humans interleukin-8 Interleukin-8 - metabolism Interleukin-8 - physiology lung disease Lung Diseases - drug therapy neutrophils Receptors, Interleukin-8A - antagonists & inhibitors Receptors, Interleukin-8A - physiology therapy |
| title | Interleukin-8 receptor antagonists in pulmonary diseases |
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