Interleukin-8 receptor antagonists in pulmonary diseases

Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines are involved in the function of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current Opinion in Pharmacology 2001-06, Vol.1 (3), p.242-247
Hauptverfasser:	Hay, Douglas W.P, Sarau, Henry M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chemokines Humans interleukin-8 Interleukin-8 - metabolism Interleukin-8 - physiology lung disease Lung Diseases - drug therapy neutrophils Receptors, Interleukin-8A - antagonists & inhibitors Receptors, Interleukin-8A - physiology therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Inflammatory cells are thought to be instrumental in the pathophysiology of pulmonary diseases, and control of their recruitment and activation in the lung would appear to be an attractive strategy for therapeutic intervention. Interleukin-8 and related CXC chemokines are involved in the function of neutrophils and T cells, and have been implicated in several lung diseases. Small-molecule antagonists of the interleukin-8 receptors have been identified, which may help elucidate the role of interleukin-8 and related chemokines in the pathophysiology of lung diseases.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/S1471-4892(01)00043-1