Cohibins C and D, Two Important Metabolites in the Biogenesis of Acetogenins from Annona muricata and Annona nutans

Two new annonaceous acetogenins, cohibins C (1a) and D (1b), have been isolated by extensive chromatography of a hexane extract of Annona muricata seeds and a cyclohexane extract of Annona nutans root bark. Their structures have been established on the basis of spectral evidence (NMR, MS) and confir...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-09, Vol.63 (9), p.1192-1196
Hauptverfasser:	Gleye, Christophe, Raynaud, Sophie, Fourneau, Christophe, Laurens, Alain, Laprévote, Olivier, Serani, Laurent, Fournet, Alain, Hocquemiller, Reynald
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry 4-Butyrolactone - metabolism Biological and medical sciences Furans - metabolism General pharmacology Lactones - metabolism Magnoliopsida - metabolism Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Seeds - metabolism Spectrum Analysis
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Beschreibung
Zusammenfassung:	Two new annonaceous acetogenins, cohibins C (1a) and D (1b), have been isolated by extensive chromatography of a hexane extract of Annona muricata seeds and a cyclohexane extract of Annona nutans root bark. Their structures have been established on the basis of spectral evidence (NMR, MS) and confirmed by chemical transformation into a pair of monotetrahydrofuran (mono-THF) acetogenins. The role of these compounds in the biogenesis of mono-THF acetogenins is discussed.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000061a