In Vitro Antiinflammatory Effects of Neolignan Woorenosides from the Rhizomes of Coptis japonica

Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (ΝΟ) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various m...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-09, Vol.63 (9), p.1205-1209
Hauptverfasser:	Cho, Jae Youl, Baik, Kyong Up, Yoo, Eun Sook, Yoshikawa, Kazuko, Park, Myung Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Cell Line General pharmacology Interleukin-2 - pharmacology Lignans - isolation & purification Lignans - pharmacology Lymphocytes - drug effects Lymphocytes - metabolism Macrophages - drug effects Macrophages - metabolism Male Medical sciences Mice Mice, Inbred BALB C Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Spleen - cytology Spleen - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Zusammenfassung:	Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-α and nitric oxide (ΝΟ) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9902791