Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fun...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-09, Vol.10 (18), p.2107-2110
Hauptverfasser:	Chen, Shu-Hui, Sun, Xicheng, Boyer, Robert, Paschal, Jonathan, Zeckner, Doug, Current, William, Zweifel, Mark, Rodriguez, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Aspergillus fumigatus - drug effects Biological and medical sciences Candida albicans - drug effects Cryptococcus neoformans - drug effects Fungi - drug effects Fungi - growth & development Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Pseudomonas - chemistry Stereoisomerism Structure-Activity Relationship
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Zusammenfassung:	A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00424-8