Activity of Extracts and Isolated Naphthoquinones from Kigelia pinnata against Plasmodium falciparum

Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9−96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 va...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-09, Vol.63 (9), p.1306-1309
Hauptverfasser:	Weiss, Claudia R, Moideen, Sulaikah V. K, Croft, Simon L, Houghton, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(1-Hydroxyethyl)naphtho(2,3-b)furan-4,9-dione Animals Antimalarials - chemistry Antimalarials - pharmacology Asteraceae - chemistry Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Humans isokigelinol Isopinnatal Kigelia pinnata kigelinol Medical sciences naphthoquinone Naphthoquinones - chemistry Naphthoquinones - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects Tumor Cells, Cultured
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Zusammenfassung:	Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9−96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9−96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000029g