TMC-135A and B, New Triene-ansamycins, Produced by Streptomyces sp

In the course of screening for new bioactive compounds, we have isolated two antibiotics from the fermentation broth of Streptomyces sp. TC 1190 and were designated TMC-135A and B. Spectroscopic analyses revealed that TMC-135s were new members of triene-ansamycins, closely related to thiazinotrienom...

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Veröffentlicht in:	Journal of antibiotics 2000/07/25, Vol.53(7), pp.724-727
Hauptverfasser:	NISHIO, MAKI, KOHNO, JUN, SAKURAI, MASAAKI, SUZUKI, SHIN-ICHI, OKADA, NOBUAKI, KAWANO, KIMIO, KOMATSUBARA, SABURO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ansamycins Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Drug Screening Assays, Antitumor Fermentation Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Spectroscopy Mice Microbiology Molecular Structure Rifabutin - analogs & derivatives Rifabutin - antagonists & inhibitors Rifabutin - chemistry Rifabutin - isolation & purification Rifabutin - pharmacology Streptomyces Streptomyces - classification Streptomyces - metabolism Structure-Activity Relationship TMC-135A agent TMC-135B agent Triene-ansamycins Tumor Cells, Cultured
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Zusammenfassung:	In the course of screening for new bioactive compounds, we have isolated two antibiotics from the fermentation broth of Streptomyces sp. TC 1190 and were designated TMC-135A and B. Spectroscopic analyses revealed that TMC-135s were new members of triene-ansamycins, closely related to thiazinotrienomycins and cytotrienins. This paper briefly describes the taxonomy, isolation, physico-chemical properties, structure elucidation and biological activity of TMC-135A and B.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.724