Phospholipase C activation by anesthetics decreases membrane-cytoskeleton adhesion

Many different amphiphilic compounds cause an increase in the fluid-phase endocytosis rates of cells in parallel with a decrease in membrane-cytoskeleton adhesion. These compounds, however, do not share a common chemical structure, which leaves the mechanism and even site of action unknown. One poss...

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Veröffentlicht in:	Journal of cell science 2001-10, Vol.114 (Pt 20), p.3759-3766
Hauptverfasser:	Raucher, D, Sheetz, M P
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Anesthetics, Local - chemistry Anesthetics, Local - pharmacology Animals Antipsychotic Agents - chemistry Antipsychotic Agents - pharmacology Calcium - metabolism Cell Membrane - chemistry Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane Permeability Chlorpromazine - chemistry Chlorpromazine - pharmacology Cytoskeleton - metabolism Enzyme Activation Estrenes - pharmacology Green Fluorescent Proteins Lasers Lidocaine - analogs & derivatives Lidocaine - pharmacology Luminescent Proteins - metabolism Mice Micromanipulation Microscopy, Confocal - methods Molecular Structure Phosphatidylinositol 4,5-Diphosphate - metabolism Phospholipids - metabolism Pyrrolidinones - pharmacology Recombinant Fusion Proteins - metabolism Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism
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