Expression of a Subset of Steroid Receptor Cofactors Is Associated with Progesterone Receptor Expression in Meningiomas
The predominance of meningiomas in females, their accelerated growth during the luteal phase of the menstrual cycle and during pregnancy, and the association between meningiomas and breast cancer have led to a number of studies examining the potential role of steroids on the growth of meningiomas. T...
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Veröffentlicht in: | Clinical cancer research 2000-09, Vol.6 (9), p.3570-3575 |
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Zusammenfassung: | The
predominance of meningiomas in females, their accelerated growth during
the luteal phase of the menstrual cycle and during pregnancy, and the
association between meningiomas and breast cancer have led to a number
of studies examining the potential role of steroids on the growth of
meningiomas. There are numerous discrepancies in the literature about
the mitogenic effects of steroids on meningiomas in both in
vitro and in vivo models. The aim of this study
was to examine the expression of three steroid receptor coactivators,
along with progesterone receptor and estrogen receptor in meningiomas.
This additional regulatory layer may explain the heterogeneity of
hormone responses observed in these tumors. Using Western blot analysis
and immunohistochemistry, we demonstrate the expression of the
steroid coactivators steroid receptor cofactor (SRC-1), amplified in
breast cancer protein (AIB1), and transcriptional intermediary factor 2
(TIF2) in 81, 76, and 76% of meningiomas, respectively. The expression
of SRC-1 and TIF2 is significantly related to progesterone but not to
estrogen receptor expression. In contrast, seven normal brain specimens
were positive for TIF2 and SRC-1 but negative for AIB1. One
leptomeningeal specimen was positive for AIB1, SRC-1, and progesterone
receptor. The differential expression of steroid receptor coactivators
may explain the differential response of these tumors to hormonal
therapy. |
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ISSN: | 1078-0432 1557-3265 |