Genetics of heart development

The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila ‘heart’ is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish...

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Veröffentlicht in:	Trends in Genetics 2000-09, Vol.16 (9), p.383-388
Hauptverfasser:	Chen, Jau-Nian, Fishman, Mark C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Evolution Body Patterning Cell differentiation, maturation, development, hematopoiesis Cell physiology Danio rerio Drosophila Fundamental and applied biological sciences. Psychology Heart - embryology Heart - physiology Mice Molecular and cellular biology Morphogenesis Mouse Vertebrata Zebrafish
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Beschreibung
Zusammenfassung:	The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila ‘heart’ is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily ‘new’ organotypic components.
ISSN:	0168-9525
DOI:	10.1016/S0168-9525(00)02075-8