Polycystin channels and kidney disease

Polycystins are a distinct family of integral membrane proteins, related by sequence and structural homology. These proteins play important roles in organ morphogenesis and function, and mutations in two of the five known members cause a common renal cystic disease. Recent data on the function of po...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2001-11, Vol.22 (11), p.543-546
Hauptverfasser:	Stayner, Cherie, Zhou, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals calcium signaling endoplasmic reticulum Humans ion channel Ion Channels - genetics Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - physiology polycystic kidney disease Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - physiopathology polycystin Proteins - chemistry Proteins - genetics Proteins - physiology transmembrane protein TRPP Cation Channels
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Beschreibung
Zusammenfassung:	Polycystins are a distinct family of integral membrane proteins, related by sequence and structural homology. These proteins play important roles in organ morphogenesis and function, and mutations in two of the five known members cause a common renal cystic disease. Recent data on the function of polycystins have revealed them to be Ca 2+-permeable cation channels and putative ion-channel regulators. Their roles in the regulation of intracellular Ca 2+ concentration and in polycystic kidney disease are discussed.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/S0165-6147(00)01832-0