Regulatory mechanisms in the pathways of cartilage and bone formation

Three transcription factors of the Sox family have essential roles in different steps of the chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is needed for osteoblast differentiation, also stimulates hypertrophic chondrocyte maturation, it links the chondrocyte and osteoblast differentiation pathways in endochondral bone formation. Signaling molecules, including Indian Hedgehog, PTHrP and FGFs, also establish essential links either between these pathways, between steps in these pathways or between signaling molecules and transcription factors, so that a more comprehensive view of endochondral bone formation is emerging. This review discusses the formation of cartilage and bone with respect to the Sox family of transcriptional regulators. Additional factors involved in this pathway include CBFA1, PTHrP and the FGFs.