VIP innervation: sharp contrast in fetal sheep and baboon adrenal glands suggests differences in developmental regulation

Immunocytochemical technique and light microscopy were used to ascertain the relationship between vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase in fetal sheep and fetal baboon adrenal cortices and medullae at 85% of gestation. VIP immunostaining was extremely robust in fetal sheep...

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Veröffentlicht in:	Brain research 2000-09, Vol.877 (2), p.271-280
Hauptverfasser:	Berghorn, Kathie A., Li, Cun, Nathanielsz, Peter W., McDonald, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Adrenal Cortex - cytology Adrenal Cortex - embryology Adrenal Cortex - innervation Adrenal Cortex - metabolism Adrenal Medulla - cytology Adrenal Medulla - embryology Adrenal Medulla - innervation Adrenal Medulla - metabolism Age Factors Animals Baboon Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Female Fetus Fetus - cytology Fetus - embryology Fetus - metabolism Fundamental and applied biological sciences. Psychology Ganglia - cytology Ganglia - embryology Ganglia - metabolism Nerve Fibers - metabolism Nerve Fibers - ultrastructure Organogenesis. Fetal development Organogenesis. Physiological fonctions Papio Papio - embryology Papio - metabolism Pregnancy Sheep Sheep - embryology Sheep - metabolism Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - metabolism Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase Vasoactive Intestinal Peptide - metabolism VIP
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Zusammenfassung:	Immunocytochemical technique and light microscopy were used to ascertain the relationship between vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase in fetal sheep and fetal baboon adrenal cortices and medullae at 85% of gestation. VIP immunostaining was extremely robust in fetal sheep adrenal cortical neurofibers and cells while weak in fibers and nonexistent in cells of fetal baboon. Also, tyrosine hydroxylase-immunopositive cells, present throughout the adrenal cortices of both fetal sheep and baboons, were heavily innervated by VIP-immunoreactive neurofibers in fetal sheep, but not in fetal baboons. Adrenal cortical VIP-immunopositive fibers occurred in greater ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(00)02683-4