C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men
Background There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Dise...
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Veröffentlicht in: | European heart journal 2000-10, Vol.21 (19), p.1584-1590 |
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Sprache: | eng |
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Zusammenfassung: | Background There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in particular whether the low grade inflammation indicated by C-reactive protein may be the mechanism whereby non-circulating risk factors may influence pathogenesis of ischaemic heart disease. Methods Plasma specimens collected during 1979–83 from 1395 men with sufficient sample remaining were assayed for serum C-reactive protein by ELISA. Subsequent mortality and incident ischaemic heart disease events were ascertained from death certificates, hospital records and electrocardiographic changes at 5-yearly follow-up examinations. Results There was a positive association between C-reactive protein and incident ischaemic heart disease (P |
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ISSN: | 0195-668X 1522-9645 |
DOI: | 10.1053/euhj.1999.1982 |