Applicability of carcinoembryonic antigen-specific monoclonal antibodies to radioimmunoguided surgery for human colorectal carcinoma

Applicability of carcinoembryonic antigen-specific monoclonal antibodies to radioimmunoguided surgery for human colorectal carcinoma

Two carcinoembryonic antigen (CEA)-specific monoclonal antibodies (MAbs), PR1A3 and T84.66, were tested to determine whether they could accurately localize colorectal carcinoma and therefore be applicable in radioimmunoguided surgery (RIGS). Twenty-one tumors by three human colorectal carcinoma cell...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2000-09, Vol.60 (17), p.4825-4829
Hauptverfasser: KIM, Jin C, KIM, Wan S, BODMER, Walter F, RYU, Jin S, OH, Seung J, LEE, Dong H, KOO, Kum H, ROH, Sun A, KIM, Hee C, YU, Chang S, KANG, Gyeong H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - pharmacokinetics
Antibodies, Monoclonal - therapeutic use
Antibody Specificity
Autoradiography - methods
Biological and medical sciences
Carcinoembryonic Antigen - immunology
Colorectal Neoplasms - diagnostic imaging
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - surgery
Digestion. Liver. Biliary tract. Spleen. Pancreas
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Mice
Mice, Nude
Neoplasm Transplantation
Radioimmunodetection - methods
Radionuclide investigations
Sensitivity and Specificity
Tissue Distribution
Tumor Cells, Cultured
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Zusammenfassung:Two carcinoembryonic antigen (CEA)-specific monoclonal antibodies (MAbs), PR1A3 and T84.66, were tested to determine whether they could accurately localize colorectal carcinoma and therefore be applicable in radioimmunoguided surgery (RIGS). Twenty-one tumors by three human colorectal carcinoma cell lines with various levels of CEA expression (KM-12c, C75, and Clone A) were successfully implanted in the intra-abdominal organs of 15 nude mice. The tumors was localized using a portable radioisotope detector (Neoprobe 1000) 48 h after injection of radiolabeled MAbs (10 mCi/mouse) when the precordial counts were
ISSN:0008-5472
1538-7445