Statistical analysis of the DNA sequence of human chromosome 22

We study statistical patterns in the DNA sequence of human chromosome 22, the first completely sequenced human chromosome. We find that (i). the 33.4 x 10(6) nucleotide long human chromosome exhibits long-range power-law correlations over more than four orders of magnitude, (ii). the entropies H(n)...

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Veröffentlicht in:	Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2001-10, Vol.64 (4 Pt 1), p.041917-419179, Article 041917
Hauptverfasser:	Holste, D, Grosse, I, Herzel, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alu Elements Chromosomes, Human, Pair 22 - ultrastructure DNA - ultrastructure Entropy Genes Genome, Human Humans Mathematical models Models, Statistical Monomers Oligonucleotides - chemistry Proteins Repetitive Sequences, Nucleic Acid Statistical methods Thermodynamics
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Zusammenfassung:	We study statistical patterns in the DNA sequence of human chromosome 22, the first completely sequenced human chromosome. We find that (i). the 33.4 x 10(6) nucleotide long human chromosome exhibits long-range power-law correlations over more than four orders of magnitude, (ii). the entropies H(n) of the frequency distribution of oligonucleotides of length n (n-mers) grow sublinearly with increasing n, indicating the presence of higher-order correlations for all of the studied lengths 1
ISSN:	1539-3755 1063-651X 1095-3787
DOI:	10.1103/PhysRevE.64.041917