Apoptosis subversion: HIV-Nef provides both armor and sword

Virologists and immunologists are all too aware of the ability of HIV to evade efforts by its human host to destroy it within the body. Now, two new pieces of evidence reveal yet more of HIV's survival abilities: the virus uses a single protein both to trigger and block apoptosis as the situati...

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Veröffentlicht in:	Nature medicine 2001-11, Vol.7 (11), p.1181-1182
1. Verfasser:	Claude Ameisen, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biomedical and Life Sciences Biomedicine Cancer Research Gene Products, nef - physiology HIV - pathogenicity HIV - physiology HIV Infections - pathology HIV Infections - virology Human immunodeficiency virus Humans Infectious Diseases Metabolic Diseases Molecular Medicine nef Gene Products, Human Immunodeficiency Virus Neurosciences news-and-views Proto-Oncogene Proteins c-bcl-2 - physiology Simian Immunodeficiency Virus - pathogenicity Simian Immunodeficiency Virus - physiology Viral Regulatory and Accessory Proteins - physiology Virus Replication
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Virologists and immunologists are all too aware of the ability of HIV to evade efforts by its human host to destroy it within the body. Now, two new pieces of evidence reveal yet more of HIV's survival abilities: the virus uses a single protein both to trigger and block apoptosis as the situation demands. (pages 1217–1224 )
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm1101-1181