Primary sequences of proteinlike copolymers: Levy-flight-type long-range correlations

Primary sequences of proteinlike copolymers: Levy-flight-type long-range correlations

We consider the statistical properties of primary sequences of two-letter HP copolymers (H for hydrophobic and P for polar) designed to have water soluble globular conformations with H monomers shielded from water inside the shell of P monomers. We show, both by computer simulations and by exact ana...

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Veröffentlicht in:Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2001-10, Vol.64 (4 Pt 1), p.040903-040903, Article 040903
Hauptverfasser: Govorun, E N, Ivanov, V A, Khokhlov, A R, Khalatur, P G, Borovinsky, A L, Grosberg, A Y
Format: Artikel
Sprache:eng
Schlagworte:
Biophysics - methods
Computer Simulation
Models, Molecular
Models, Statistical
Molecular Conformation
Monte Carlo Method
Poisson Distribution
Polymers - chemistry
Protein Conformation
Protein Structure, Secondary
Thermodynamics
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Zusammenfassung:We consider the statistical properties of primary sequences of two-letter HP copolymers (H for hydrophobic and P for polar) designed to have water soluble globular conformations with H monomers shielded from water inside the shell of P monomers. We show, both by computer simulations and by exact analytical calculation, that for large globules and flexible polymers such sequences exhibit long-range correlations which can be described by Levy-flight statistics.
ISSN:1539-3755
1063-651X
1095-3787
DOI:10.1103/PhysRevE.64.040903