Coronary heart disease in smokers: Vitamin C restores coronary microcirculatory function

Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicar...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-09, Vol.102 (11), p.1233-1238
Hauptverfasser:	KAUFMANN, Philipp A, GNECCHI-RUSCONE, Tomaso, DI TERLIZZI, Marco, SCHÄFERS, Klaus P, LÜSCHER, Thomas F, CAMICI, Paolo G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antioxidants - pharmacology Ascorbic Acid - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiology. Vascular system Coronary heart disease Coronary Vessels - drug effects Coronary Vessels - physiology Dose-Response Relationship, Drug Electrocardiography Heart Heart Rate - drug effects Humans Male Medical sciences Microcirculation Middle Aged Oxidative Stress Pericardium - physiology Regional Blood Flow - drug effects Smoking - adverse effects Tomography, Emission-Computed Vascular Resistance - drug effects
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Zusammenfassung:	Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P:
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.102.11.1233