Progressive Infection in a Subset of HIV-1—Positive Chimpanzees

Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)—1; however, infected animals usually maintain normal numbers of CD4+ T lymphocytes and do not develop immunodeficiency. We have examined 10 chronically infected HIV-1—positive chimpanzees for evidence of progressive inf...

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Veröffentlicht in:	The Journal of infectious diseases 2000-10, Vol.182 (4), p.1051-1062
Hauptverfasser:	O'Neil, Shawn P., Novembre, Francis J., Hill, Anne Brodie, Suwyn, Carolyn, Hart, Clyde E., Evans-Strickfaden, Tammy, Anderson, Daniel C., deRosayro, Juliette, Herndon, James G., Saucier, Michelle, McClure, Harold M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - physiopathology ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 AIDS Animals Antigens, CD Antigens, Differentiation - blood Biological and medical sciences CD38 antigen CD4 antigen CD4 Lymphocyte Count CD4-CD8 Ratio CD8 antigen Disease Progression Experimental viral diseases and models Female HIV HIV 1 HIV infections HIV Infections - immunology HIV Infections - pathology HIV Infections - physiopathology HIV Seropositivity - immunology HIV Seropositivity - pathology HIV Seropositivity - physiopathology HLA-DR Antigens - blood Human immunodeficiency virus 1 Humans Infections Infectious diseases Integrin beta1 - blood Lymph nodes Lymph Nodes - pathology Lymph Nodes - virology Lymphocyte Subsets - immunology Lymphocytes Major Articles Male Medical sciences Membrane Glycoproteins NAD+ Nucleosidase - blood Pan troglodytes Receptors, Interleukin-2 - blood RNA T lymphocytes T-Lymphocytes - immunology Time Factors Viral diseases Viruses
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Zusammenfassung:	Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)—1; however, infected animals usually maintain normal numbers of CD4+ T lymphocytes and do not develop immunodeficiency. We have examined 10 chronically infected HIV-1—positive chimpanzees for evidence of progressive infection. In addition to 1 animal that developed AIDS, 3 chimpanzees exhibit evidence of progressive HIV infection. All progressors have low CD4+ T cell counts (
ISSN:	0022-1899 1537-6613
DOI:	10.1086/315823