New 24-Isopropylcholesterol and 24-Isopropenylcholesterol Sulfate from the Marine Sponge Epipolasis Species

Two novel steroids, polasterol A (1) and polasterol B sulfate (2), along with two known compounds, 22(E),24-isopropylcholesta-5,22-dien-3β-ol (3) and halistanol sulfate (4), have been isolated from the Japanese marine sponge Epipolasis sp. The structures of 1 and 2 were determined as 3β-hydroxy-24-i...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-08, Vol.63 (8), p.1175-1177
Hauptverfasser:	Umeyama, Akemi, Adachi, Kanako, Ito, Seiichi, Arihara, Shigenobu
Format:	Artikel
Sprache:	eng
Schlagworte:	24-Isopropylcholesterol 24-Isopropylcholesterol sulfate Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cholesterol - analogs & derivatives Cholesterol - chemistry Cholesterol - isolation & purification Chromatography, Gel Epipolasis Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Japan Magnetic Resonance Spectroscopy Marine natural products Optical Rotation Other biological molecules polasterol A polasterol B sulfate Porifera - chemistry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Steroids - chemistry Steroids - isolation & purification Terpenes, steroids. Hormones
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Beschreibung
Zusammenfassung:	Two novel steroids, polasterol A (1) and polasterol B sulfate (2), along with two known compounds, 22(E),24-isopropylcholesta-5,22-dien-3β-ol (3) and halistanol sulfate (4), have been isolated from the Japanese marine sponge Epipolasis sp. The structures of 1 and 2 were determined as 3β-hydroxy-24-isopropylcholesta-5,22(E)-dien-7-one and 24ξ-isopropenylcholesta-22(Z),28(29)-diene-2β,3α,6α-triyl trisodium sulfate on the basis of spectroscopic investigations and a chemical conversion.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000024j