Effects of low-dose losartan treatment on persistent microalbuminuria in normotensive Type 1 diabetic subjects
To examine the effect of low-dose losartan, an angiotensin II antagonist, on persistent microalbuminuria in normotensive Type 1 diabetes mellitus, 16 subjects with Type 1 diabetes were randomly assigned to two 2-month treatment periods, with either losartan (25 mg/day) or enalapril (5 mg/day) in a s...
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Veröffentlicht in: | Journal of endocrinological investigation 2001-09, Vol.24 (8), p.608-611 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To examine the effect of low-dose losartan, an angiotensin II antagonist, on persistent microalbuminuria in normotensive Type 1 diabetes mellitus, 16 subjects with Type 1 diabetes were randomly assigned to two 2-month treatment periods, with either losartan (25 mg/day) or enalapril (5 mg/day) in a single-blind cross-over design. Urinary albumin excretion (UAE), blood pressures, lipids, glycemia, HbA1C, serum potassium and creatinine clearance were measured before and after each treatment period. The UAEs were similarly reduced after both treatments. The median UAE decreased by 27.8%, from 162 (range 65-250) to 117 (34-190) mg/day (p |
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ISSN: | 0391-4097 1720-8386 |
DOI: | 10.1007/BF03343901 |