p53 Protein expression and proliferative activity in ductal breast carcinomas

p53 Protein expression and proliferative activity in ductal breast carcinomas The immunocytochemical expression of p53 protein and Ki‐67 labelling index in tumour cells of 100 ductal breast carcinomas of different histological grade and stage was evaluated in cytological material. In order to investigate p53 expression and Ki‐67 expression an avidin‐extravidin immunocytochemical technique was applied to imprints. Monoclonal antibody (MoAb) DO‐p53 and proliferating cell monoclonal antibody were used as primary antibodies. A statistically significant difference was observed between p53 protein expression and grade of malignancy and clinical stage (P = 0.001, P