Muscle afferent-pituitary axis: a novel pathway for modulating the secretion of a pituitary growth factor

Evidence is presented for a novel muscle-neuro-endocrine pathway for modulating the secretion of an unidentified pituitary growth factor by proprioceptive input from skeletal muscle afferents. Exercise stimulates the release of this growth factor, whereas chronic unloading associated with bed rest o...

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Veröffentlicht in:	Exercise and sport sciences reviews 2001-10, Vol.29 (4), p.164-169
Hauptverfasser:	McCall, G E, Gosselink, K L, Bigbee, A J, Roy, R R, Grindeland, R E, Edgerton, V R
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - physiology Animals Electric Stimulation Exercise - physiology Growth Hormone - secretion Humans Muscle Contraction - physiology Muscle, Skeletal - innervation Pituitary Gland - physiology Proprioception - physiology Space Flight
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Beschreibung
Zusammenfassung:	Evidence is presented for a novel muscle-neuro-endocrine pathway for modulating the secretion of an unidentified pituitary growth factor by proprioceptive input from skeletal muscle afferents. Exercise stimulates the release of this growth factor, whereas chronic unloading associated with bed rest or spaceflight abrogates the normal exercise stimulus.
ISSN:	0091-6331
DOI:	10.1097/00003677-200110000-00006