Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA

To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2001-11, Vol.56 (11), p.B483-B485
Hauptverfasser:	Tsurudome, Y, Hirano, T, Hirata, K, Higure, A, Nagata, N, Takahashi, K, Itoh, H, Kasai, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging Aging - metabolism Colon - metabolism Colonic Polyps - metabolism Colorectal cancer Colorectal Neoplasms - metabolism Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism Gerontology Guanine - analogs & derivatives Guanine - analysis Guanine - metabolism Humans Intestinal Polyps - metabolism Medical research Middle Aged Oxidation Oxidative Stress Rectum - metabolism
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Zusammenfassung:	To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/56.11.b483