Surface plasmon resonance sensor using molecularly imprinted polymer for detection of sialic acid

A surface plasmon resonance (SPR) sensor using a molecularly imprinted polymer-coated sensor chip for the detection of sialic acid was developed. The thinly coated polymer was prepared by co-polymerizing N, N, N-trimethylaminoethyl methacrylate, 2-hydroxyethyl methacrylate and ethyleneglycol dimetha...

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Veröffentlicht in:Biosensors & bioelectronics 2001-12, Vol.16 (9), p.1059-1062
Hauptverfasser: Kugimiya, Akimitsu, Takeuchi, Toshifumi
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creator Kugimiya, Akimitsu
Takeuchi, Toshifumi
description A surface plasmon resonance (SPR) sensor using a molecularly imprinted polymer-coated sensor chip for the detection of sialic acid was developed. The thinly coated polymer was prepared by co-polymerizing N, N, N-trimethylaminoethyl methacrylate, 2-hydroxyethyl methacrylate and ethyleneglycol dimethacrylate in the presence of p-vinylbenzeneboronic acid ester with sialic acid. The sensor showed a selective response to ganglioside of which sialic acid is located at the non-reducing end and gave a linear relationship from 0.1 to 1.0 mg of ganglioside.
doi_str_mv 10.1016/S0956-5663(01)00227-5
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Analytical biochemistry: general aspects, technics, instrumentation
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomimetic sensor
Fundamental and applied biological sciences. Psychology
G(M1) Ganglioside - analysis
G(M1) Ganglioside - chemistry
Ganglioside
Molecular imprinting
N-Acetylneuraminic Acid - analysis
Polymers - chemistry
Sialic acid
Surface plasmon resonance
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
title Surface plasmon resonance sensor using molecularly imprinted polymer for detection of sialic acid
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