Surface plasmon resonance sensor using molecularly imprinted polymer for detection of sialic acid

A surface plasmon resonance (SPR) sensor using a molecularly imprinted polymer-coated sensor chip for the detection of sialic acid was developed. The thinly coated polymer was prepared by co-polymerizing N, N, N-trimethylaminoethyl methacrylate, 2-hydroxyethyl methacrylate and ethyleneglycol dimetha...

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Veröffentlicht in:	Biosensors & bioelectronics 2001-12, Vol.16 (9), p.1059-1062
Hauptverfasser:	Kugimiya, Akimitsu, Takeuchi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Biological and medical sciences Biomimetic sensor Fundamental and applied biological sciences. Psychology G(M1) Ganglioside - analysis G(M1) Ganglioside - chemistry Ganglioside Molecular imprinting N-Acetylneuraminic Acid - analysis Polymers - chemistry Sialic acid Surface plasmon resonance Surface Plasmon Resonance - instrumentation Surface Plasmon Resonance - methods
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Zusammenfassung:	A surface plasmon resonance (SPR) sensor using a molecularly imprinted polymer-coated sensor chip for the detection of sialic acid was developed. The thinly coated polymer was prepared by co-polymerizing N, N, N-trimethylaminoethyl methacrylate, 2-hydroxyethyl methacrylate and ethyleneglycol dimethacrylate in the presence of p-vinylbenzeneboronic acid ester with sialic acid. The sensor showed a selective response to ganglioside of which sialic acid is located at the non-reducing end and gave a linear relationship from 0.1 to 1.0 mg of ganglioside.
ISSN:	0956-5663 1873-4235
DOI:	10.1016/S0956-5663(01)00227-5