Polyacetylene Carboxylic Acids from Mitrephora celebica

A new polyacetylene carboxylic acid, 13(E),17-octadecadiene-9,11-diynoic acid (13,14-dihydrooropheic acid, 1), and the known 17-octadecene-9,11,13-triynoic acid (oropheic acid, 2) were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Both compounds demonstrat...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-10, Vol.64 (10), p.1348-1349
Hauptverfasser:	ZGODA, Joanna R., FREYER, Alan J., KILLMER, Lew B., PORTER, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylene - analogs & derivatives Acetylene - chemistry Acetylene - isolation & purification Acetylene - pharmacology Alkynes Annonaceae - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biological and medical sciences Carboxylic Acids - chemistry Carboxylic Acids - isolation & purification Carboxylic Acids - pharmacology Diynes Drug Evaluation, Preclinical Drug Resistance, Microbial General pharmacology Indonesia Magnetic Resonance Spectroscopy Medical sciences Methicillin - pharmacology Molecular Structure Mycobacterium smegmatis Mycobacterium smegmatis - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Stems - chemistry Plants, Medicinal - chemistry Polymers - chemistry Polymers - isolation & purification Polymers - pharmacology Polyynes Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Staphylococcus aureus Staphylococcus aureus - drug effects
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Beschreibung
Zusammenfassung:	A new polyacetylene carboxylic acid, 13(E),17-octadecadiene-9,11-diynoic acid (13,14-dihydrooropheic acid, 1), and the known 17-octadecene-9,11,13-triynoic acid (oropheic acid, 2) were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Both compounds demonstrated significant activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0102509