Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: Results of a multicenter study

Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: Results of a multicenter study

Orthotopic liver transplantation (OLT) offers the only chance to eliminate both tumor and liver disease in patients with hepatocellular carcinoma (HCC) and cirrhosis. However, tumor progression while on the waiting list and recurrence after OLT are frequent. We undertook a large multicenter study to...

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Veröffentlicht in:Liver transplantation 2001-10, Vol.7 (10), p.877-883
Hauptverfasser: Figueras, Juan, Ibañez, Luis, Ramos, Emilio, Jaurrieta, Eduardo, Ortiz-de-Urbina, Jorge, Pardo, Fernando, Mir, José, Loinaz, Carmelo, Herrera, Luis, López-Cillero, Pedro, Santoyo, Julio
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Analysis of Variance
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Female
Follow-Up Studies
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - pathology
Liver Cirrhosis - surgery
Liver Neoplasms - complications
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver Transplantation
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Patient Selection
Probability
Retrospective Studies
Survival Analysis
Treatment Outcome
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Zusammenfassung:Orthotopic liver transplantation (OLT) offers the only chance to eliminate both tumor and liver disease in patients with hepatocellular carcinoma (HCC) and cirrhosis. However, tumor progression while on the waiting list and recurrence after OLT are frequent. We undertook a large multicenter study to assess survival and related factors of recurrence after OLT. This retrospective study analyses data from 307 consecutive patients with HCC and cirrhosis treated with OLT between 1990 and 1997 in eight centers in Spain. OLT was indicated only for small (
ISSN:1527-6465
1527-6473
DOI:10.1053/jlts.2001.27856