Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4
The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented. The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in v...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2001-11, Vol.11 (22), p.2955-2958 |
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| container_end_page | 2958 |
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| container_issue | 22 |
| container_start_page | 2955 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 11 |
| creator | Wattanasin, Sompong Weidmann, Beat Roche, Didier Myers, Stewart Xing, Amy Guo, Qin Sabio, Michael von Matt, Peter Hugo, Ronald Maida, Susan Lake, Philip Weetall, Marla |
| description | The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.
The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are alsopresented. |
| doi_str_mv | 10.1016/S0960-894X(01)00586-8 |
| format | Article |
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The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are alsopresented.</description><subject>Anti-Allergic Agents - antagonists & inhibitors</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Drug Design</subject><subject>Immunomodulators</subject><subject>Integrin alpha4beta1</subject><subject>Integrins - antagonists & inhibitors</subject><subject>Medical sciences</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Lymphocyte Homing - antagonists & inhibitors</subject><subject>Receptors, Very Late Antigen - antagonists & inhibitors</subject><subject>Structure-Activity Relationship</subject><subject>Urea - chemistry</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMouq7-BKUXRQ_VpJ007UnE58KCgg-8hTSd7ka6qSZdYf-9cVv06GmY4ZvXR8gBo2eMsuz8iRYZjfMC3k4oO6WU51mcb5ARgwziFCjfJKNfZIfsev9OKQMKsE12GMuEYCmMyOQavZnZSNkqelrZbh5SH7V19Nh2aLu-jg3qznxhNLFzU5qudWtkYjucOWOj1-llDHtkq1aNx_0hjsnL7c3z1X08fbibXF1OYw1cdHFSgC40Z5ylKWiEAnOdoAIFLONC51wVFUNW8qriSkMqMgHhHeA15VrnZTomx_3cD9d-LtF3cmG8xqZRFtullyJJEpHkNIC8B7VrvXdYyw9nFsqtJKPyx6FcO5Q_giRlcu1Q5qHvcFiwLBdY_XUN0gJwNADKa9XUTllt_B8HYTgXWeAueg6Dji-DTnpt0GqsjAtCZdWaf075BiGqjII</recordid><startdate>20011119</startdate><enddate>20011119</enddate><creator>Wattanasin, Sompong</creator><creator>Weidmann, Beat</creator><creator>Roche, Didier</creator><creator>Myers, Stewart</creator><creator>Xing, Amy</creator><creator>Guo, Qin</creator><creator>Sabio, Michael</creator><creator>von Matt, Peter</creator><creator>Hugo, Ronald</creator><creator>Maida, Susan</creator><creator>Lake, Philip</creator><creator>Weetall, Marla</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011119</creationdate><title>Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4</title><author>Wattanasin, Sompong ; Weidmann, Beat ; Roche, Didier ; Myers, Stewart ; Xing, Amy ; Guo, Qin ; Sabio, Michael ; von Matt, Peter ; Hugo, Ronald ; Maida, Susan ; Lake, Philip ; Weetall, Marla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-294c9c5151334ce49e8c2ea4a41657c85a9d1e1b5dd5ac43767434045f05cc8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-Allergic Agents - antagonists & inhibitors</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. 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The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are alsopresented.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11677134</pmid><doi>10.1016/S0960-894X(01)00586-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (22), p.2955-2958 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anti-Allergic Agents - antagonists & inhibitors Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Drug Design Immunomodulators Integrin alpha4beta1 Integrins - antagonists & inhibitors Medical sciences Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Pharmacology. Drug treatments Receptors, Lymphocyte Homing - antagonists & inhibitors Receptors, Very Late Antigen - antagonists & inhibitors Structure-Activity Relationship Urea - chemistry |
| title | Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4 |
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