Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4

The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented. The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in v...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-11, Vol.11 (22), p.2955-2958
Hauptverfasser:	Wattanasin, Sompong, Weidmann, Beat, Roche, Didier, Myers, Stewart, Xing, Amy, Guo, Qin, Sabio, Michael, von Matt, Peter, Hugo, Ronald, Maida, Susan, Lake, Philip, Weetall, Marla
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Allergic Agents - antagonists & inhibitors Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Drug Design Immunomodulators Integrin alpha4beta1 Integrins - antagonists & inhibitors Medical sciences Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Pharmacology. Drug treatments Receptors, Lymphocyte Homing - antagonists & inhibitors Receptors, Very Late Antigen - antagonists & inhibitors Structure-Activity Relationship Urea - chemistry
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Zusammenfassung:	The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented. The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are alsopresented.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00586-8