Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans
We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results con...
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| Veröffentlicht in: | Experimental Gerontology 2001-11, Vol.36 (10), p.1609-1617 |
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| container_title | Experimental Gerontology |
| container_volume | 36 |
| creator | Johnson, Thomas E. de Castro, Edouard Hegi de Castro, Sarah Cypser, James Henderson, Sam Tedesco, Pat |
| description | We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results consistent with this hypothesis. Correlations between stress resistance and longevity among many gerontogene mutants is provided. |
| doi_str_mv | 10.1016/S0531-5565(01)00144-9 |
| format | Article |
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| ispartof | Experimental Gerontology, 2001-11, Vol.36 (10), p.1609-1617 |
| issn | 0531-5565 1873-6815 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging - genetics Aging mutants Animals Caenorhabditis elegans - physiology Disease Susceptibility Genetic Pathways Longevity Molecular genetics Mutation - physiology Oxidative stress Reactive oxidants Senescence Stress resistance Stress, Physiological - etiology Thermotolerance |
| title | Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans |
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