Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans

We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results con...

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Veröffentlicht in:	Experimental Gerontology 2001-11, Vol.36 (10), p.1609-1617
Hauptverfasser:	Johnson, Thomas E., de Castro, Edouard, Hegi de Castro, Sarah, Cypser, James, Henderson, Sam, Tedesco, Pat
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging mutants Animals Caenorhabditis elegans - physiology Disease Susceptibility Genetic Pathways Longevity Molecular genetics Mutation - physiology Oxidative stress Reactive oxidants Senescence Stress resistance Stress, Physiological - etiology Thermotolerance
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Beschreibung
Zusammenfassung:	We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results consistent with this hypothesis. Correlations between stress resistance and longevity among many gerontogene mutants is provided.
ISSN:	0531-5565 1873-6815
DOI:	10.1016/S0531-5565(01)00144-9