Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants

HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-08, Vol.16 (12), p.1183-1189
Hauptverfasser:	JANSSENS, W, SALMINEN, M. O, LAUKKANEN, T, HEYNDRICKX, L, VAN DER AUWERA, G, COLEBUNDERS, R, MCCUTCHAN, F. E, VAN DER GROEN, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa, Central Africa, Western AIDS/HIV Belgium Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics Genome, Viral HIV Infections - virology HIV-1 - classification HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus 1 Humans Microbiology Phylogeny Recombination, Genetic Sequence Alignment Virology
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Zusammenfassung:	HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes. We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation" recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.
ISSN:	0889-2229 1931-8405
DOI:	10.1089/088922200415045