Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists
New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of...
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| Veröffentlicht in: | European journal of medicinal chemistry 2000-07, Vol.35 (7), p.663-676 |
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| container_end_page | 676 |
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| container_issue | 7 |
| container_start_page | 663 |
| container_title | European journal of medicinal chemistry |
| container_volume | 35 |
| creator | Sánchez, Isabel Dolors Pujol, Maria Guillaumet, Gerald Massingham, Roy Monteil, André Dureng, Georges Winslow, Eileen |
| description | New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. |
| doi_str_mv | 10.1016/S0223-5234(00)00164-1 |
| format | Article |
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| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2000-07, Vol.35 (7), p.663-676 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1,4-benzodioxin 2,3-dihydro-1,4-benzodioxin Animals Aorta - drug effects Aorta - physiology Biological and medical sciences calcium channel antagonists Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology Calmodulin - antagonists & inhibitors calmodulin antagonists Cardiovascular system Dioxins - chemistry Drug Design In Vitro Techniques Magnetic Resonance Spectroscopy Male Medical sciences Miscellaneous Molecular Structure Muscle Contraction - drug effects Pharmacology. Drug treatments Rabbits Spectrophotometry, Infrared |
| title | Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists |
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