Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists

New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of...

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Veröffentlicht in:	European journal of medicinal chemistry 2000-07, Vol.35 (7), p.663-676
Hauptverfasser:	Sánchez, Isabel, Dolors Pujol, Maria, Guillaumet, Gerald, Massingham, Roy, Monteil, André, Dureng, Georges, Winslow, Eileen
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-benzodioxin 2,3-dihydro-1,4-benzodioxin Animals Aorta - drug effects Aorta - physiology Biological and medical sciences calcium channel antagonists Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology Calmodulin - antagonists & inhibitors calmodulin antagonists Cardiovascular system Dioxins - chemistry Drug Design In Vitro Techniques Magnetic Resonance Spectroscopy Male Medical sciences Miscellaneous Molecular Structure Muscle Contraction - drug effects Pharmacology. Drug treatments Rabbits Spectrophotometry, Infrared
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Beschreibung
Zusammenfassung:	New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/S0223-5234(00)00164-1