Proton spin-spin relaxation study of molecular dynamics and proteoglycan hydration in articular cartilage

Proton spin-spin relaxation study of molecular dynamics and proteoglycan hydration in articular cartilage

Spin-spin relaxation of proton magnetization in natural and deuterated articular cartilage is reported over a range of hydration. Information about macromolecular dynamics is deduced and a hydration stabilized macromolecular regime identified. There is good correspondence between NMR results and car...

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Veröffentlicht in:Biomaterials 2000-10, Vol.21 (20), p.2089-2095
Hauptverfasser: GHIASSI-NEJAD, M, TORZILLI, P. A, PEEMOELLER, H, PINTAR, M. M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cartilage, Articular - chemistry
Cattle
Hydration
Investigative techniques, diagnostic techniques (general aspects)
Macromolecules
Medical sciences
Molecular dynamics
Nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Osteoarticular system. Muscles
proteoglycans
Proteoglycans - chemistry
Protons
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Relaxation processes
Stoichiometry
Water - chemistry
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Zusammenfassung:Spin-spin relaxation of proton magnetization in natural and deuterated articular cartilage is reported over a range of hydration. Information about macromolecular dynamics is deduced and a hydration stabilized macromolecular regime identified. There is good correspondence between NMR results and cartilage stoichiometry. A new measure for hydration of proteoglycans is found.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(00)00140-X