Molecular biology of Streptococcus pneumoniae: an everlasting challenge

Streptococcus pneumoniae is a model for elucidating: 1) recombination steps of DNA, from its discovery to polarity of integration; 2) long-patch mismatch repair, short-patch repair triggered by A/G and exclusion of deletions; 3) resistance to β-lactam antibiotics; and 4) factors of virulence. Severa...

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Veröffentlicht in:	Research in microbiology 2000-07, Vol.151 (6), p.407-411
Hauptverfasser:	Sicard, Michel, Gasc, Anne Marie, Giammarinaro, Philippe, Lefrançois, Jacques, Pasta, Frank, Samrakandi, Mustapha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibiotic resistance Bacteriology Base Pair Mismatch beta-Lactam Resistance Biological and medical sciences DNA Repair Fundamental and applied biological sciences. Psychology Genetics Mice Microbiology Models, Genetic Pneumococcal Infections - microbiology recombination Recombination, Genetic Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - pathogenicity Virulence
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Zusammenfassung:	Streptococcus pneumoniae is a model for elucidating: 1) recombination steps of DNA, from its discovery to polarity of integration; 2) long-patch mismatch repair, short-patch repair triggered by A/G and exclusion of deletions; 3) resistance to β-lactam antibiotics; and 4) factors of virulence. Several of these topics remain a challenge for future investigations.
ISSN:	0923-2508 1769-7123
DOI:	10.1016/S0923-2508(00)00176-5