Perinatal factors associated with severe intracranial hemorrhage

Objective: The purpose of this study was to assess the incidence of perinatal factors that are associated with severe intracranial hemorrhage in a large and recent multicenter experience. Study Design: Retrospective analyses of nonanomalous newborns who were admitted to 100 neonatal intensive care u...

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Veröffentlicht in:American journal of obstetrics and gynecology 2001-10, Vol.185 (4), p.859-862
Hauptverfasser: Thorp, James A., Jones, Philip G., Clark, Reese H., Knox, Eric, Peabody, Joyce L.
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Sprache:eng
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Zusammenfassung:Objective: The purpose of this study was to assess the incidence of perinatal factors that are associated with severe intracranial hemorrhage in a large and recent multicenter experience. Study Design: Retrospective analyses of nonanomalous newborns who were admitted to 100 neonatal intensive care units from 23 to 34 6/7 weeks' gestation were analyzed by multiple regression. Results: There were 12,578 premature newborns with a mean ( ± SD) gestational age of 31.3 ± 2.9 weeks and a birth weight of 1685 ± 571 g, respectively. The overall incidence of severe intracranial hemorrhage was 2.9%; in 4575 newborns who weighed ≤1500 g the incidences of intracranial hemorrhage was 7.1%. Factors with positive and negative associations with severe intracranial hemorrhage are listed in order of decreasing statistical significance: gestational age (negative), surfactant (positive), antenatal indomethacin (positive), neonatal transport (positive), cesarean birth (negative), poor prenatal care (positive), 5-minute Apgar score of
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2001.117355