Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion

We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting i...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2001-09, Vol.28 (6), p.623-625
Hauptverfasser:	AMROLIA, P. J, RAO, K, SLATER, O, RAMSAY, A, VEYS, P. A, WEBB, D. K. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive immunotherapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens Biological and medical sciences Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - immunology Bone marrow, stem cells transplantation. Graft versus host reaction Child Fatal Outcome Graft vs Host Disease - etiology Graft-versus-host reaction Histocompatibility Histocompatibility antigen HLA Humans Immunotherapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Lymphocyte Transfusion - adverse effects Lymphocytes Male Medical sciences Stem cell transplantation Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous - adverse effects Transplantation, Homologous - immunology
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Zusammenfassung:	We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1703195